Lipodystrophy is a clinical syndrome characterized by an unusual distribution of fat in the body. This can relate to both fat loss (lipoatrophy) and unusual fat tissue aggregation. The disease can be inherited (for example, parental partial lipodystrophy, or FPLD) or obtained. It may be present from birth if it is inherited (congenital). The procured form can develop as a result of infectious disease, autoimmune illness, trauma, or repetitive pressure, or injury to a specific area of the body. (For instance, if you have diabetes and inject insulin in the very same spot each day, you may develop lipodystrophy at the site of injection.)

To make a clinical condition of lipodystrophy, the doctor will first examine the abnormal aesthetic due to changes in fat loss or gain, and then take a glance at the typical clinical symptoms. Other essential diagnostic tests include blood tests to assess leptin levels as well as confirm the existence of other metabolic problems (such as insulin resistance, diabetes, or blood pressure lipid levels), but not all patients with lipodystrophy have low leptin levels. Genetic screening may be conducted to determine whether a patient has a genetic mutation that creates the inherited form.

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